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The cast has undergone major changes through the series' run, with many members leaving and being replaced by others.

In its twelfth season, the show had a large ensemble of sixteen actors, including four characters from the original cast (Meredith Grey, Alex Karev, Miranda Bailey, and Richard Webber).

[...] My sisters and I would call each other up and talk about operations we'd seen on the Discovery Channel.

There's something fascinating about the medical world—you see things you'd never imagine, like the fact that doctors talk about their boyfriends or their day while they're cutting somebody open.

Rhimes has said that if the network had not allowed to create characters this way, she would have been hesitant about moving forward with the series.

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In its fourteenth season, it is ABC's highest-rated drama.

She is killed with Mark Sloan in the season eight finale.

Other additions include Leah Murphy (Tessa Ferrer), who departs near the end of the tenth season, but returns during the thirteenth; Shane Ross (Gaius Charles), who departs with Yang in the tenth-season finale; Stephanie Edwards (Jerrika Hinton), who resigns during season thirteen; Jo Wilson (Camilla Luddington), a doctor who begins a romantic relationship with Karev; Andrew Deluca (Giacomo Gianniotti), the love-interest of Meredith's half-sister Maggie Pierce (Kelly Mc Creary), who also serves as head of cardio; and Benjamin Warren (Jason George), an anesthesiologist-turned-resident, who has to balance his own desire to succeed with his wife Miranda Bailey's new role as Chief of Surgery.

Since its inception, the show has been described by the media outlets as a television "phenomenon" or a "juggernaut", owing to its longevity and dominant ratings.

It is considered to have had a significant effect on popular culture and has received numerous awards, including the Golden Globe Award for Best Television Series – Drama.

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